New insights into the mechanisms of EZH2’s promotion of oncogenesis

EZH2 is an important enzymatic subunit of the epigenetic regulator polycomb repressive complex 2 (PRC2), which includes EED and SUZ12 subunits. EZH2 functions as a methyltransferase that targets the lysine 27 of histone H3, leading to trimethylation (H3K27me3), a mechanism of post-translational modification that leads to transcriptional repression of PRC2 target genes (1).