Clinical experience and long-term outcome after subscleral insertion of a cyclosporine A drug delivery device in horses with immune-mediated keratitis

The purpose of this study was to determine the efficacy and duration of effect of a subscleral cyclosporine A implant in horses with immune-mediated keratitis (IMMK).The study at hand describes the cases of fifteen horses with mature IMMK that were presented to the Tierklinik Hochmoor for further treatment.In theses horses, a cyclosporine A drug delivery device was placed subsclerally adjacent to the suprachoroidal space under general anesthesia.Follow-up was evaluated for up to 53 months duration after implant placement.Objective assessment showed an improvement in 66.7% of patients.Four of the patients suffered a recurrence of symptoms.This study yields promising results for the long-term treatment of IMMK in horses.Sport horses and patients suffering from frequently recurring episodes of IMMK could benefit greatly from this alternative treatment method.