▼ Bezlotoxumab for prevention of recurrence of Clostridium difficile infection

Clostridium difficile infection is a significant cause of infectious diarrhoea and is associated with considerable morbidity and mortality.^1,2 Management of Clostridium difficile infection often requires treatment with antibiotics (metronidazole, vancomycin or fidaxomicin) alongside supportive care to manage hydration, electrolytes and nutrition. However, the risk of recurrence is approximately 20%.² Here, we review the evidence for bezlotoxumab (▼ Zinplava - Merck Sharp & Dohme Limited), a monoclonal antibody licensed for the prevention of recurrence of Clostridium difficile in adults who are at high risk of recurrence.