医学
自身抗体
神经炎症
脉络丛
小胶质细胞
免疫学
中枢神经系统
疾病
系统性红斑狼疮
免疫系统
红斑狼疮
神经科学
病理
抗体
炎症
生物
内科学
作者
Jia‐Ning Wang,Junmei Xu,Yang Pingting
标识
DOI:10.1016/j.jaut.2022.102892
摘要
Patients with systemic lupus erythematosus (SLE) frequently suffer from nervous system complications, termed neuropsychiatric lupus erythematosus (NPLE). NPLE accounts for the poor prognosis of SLE. Correct attribution of NP events to SLE is the primary principle in managing NPLE. The vascular injuries and neuroinflammation are the fundamental neuropathologic changes in NPLE. Specific autoantibody-mediated central nerve system (CNS) damages distinguish NPLE from other CNS disorders. Though the central antibodies in NPLE are generally thought to be raised from the periphery immune system, they may be produced in the meninges and choroid plexus. On this basis, abnormal activation of microglia and disease-associated microglia (DAM) should be the common mechanisms of NPLE and other CNS disturbances. Improved understanding of both characteristic and sharing features of NPLE might yield further options for managing this disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI