刺
免疫疗法
干扰素基因刺激剂
生物材料
信号转导
癌症研究
癌症免疫疗法
医学
神经科学
生物
免疫系统
先天免疫系统
免疫学
细胞生物学
工程类
生物医学工程
航空航天工程
作者
Yingqi Liu,Fei Yang,Xuan Wang,Bingbing Yang,Menghuan Li,Zhong Luo
标识
DOI:10.1016/j.ymthe.2023.03.026
摘要
cGAS-STING signaling is a central component in the therapeutic action of most existing cancer therapies. The accumulated knowledge of tumor immunoregulatory network in recent years has spurred the development of cGAS-STING agonists for tumor treatment as an effective immunotherapeutic strategy. However, the clinical translation of these agonists is thus far unsatisfactory because of the low immunostimulatory efficacy and unrestricted side effects under clinically relevant conditions. Interestingly, the rational integration of biomaterial technology offers a promising approach to overcome these limitations for more effective and safer cGAS-STING-mediated tumor therapy. Herein, we first outline the cGAS-STING signaling axis and generally discuss its association with tumors. We then symmetrically summarize the recent progress in those biomaterial-based cGAS-STING agonism strategies to generate robust antitumor immunity, categorized by the chemical nature of those cGAS-STING stimulants and carrier substrates. Finally, a perspective is provided to discuss the existing challenges and potential opportunities in cGAS-STING modulation for tumor therapy.
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