氧气
氧气张力
大脑皮层
脑血流
神经科学
缺氧(环境)
神经影像学
缺氧
化学
生物
麻醉
医学
有机化学
作者
Felix Beinlich,Antonis Asiminas,Verena Untiet,Zuzanna Bojarowska,Virginia Plá,Björn Sigurðsson,Vincenzo Timmel,Lukas Gehrig,Michael H. Graber,Hajime Hirase,Maiken Nedergaard
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-03-29
卷期号:383 (6690): 1471-1478
标识
DOI:10.1126/science.adn1011
摘要
Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes. Yet only rudimentary knowledge exists regarding cortical partial oxygen tension (Po2) dynamics under physiological conditions. Here we introduce Green enhanced Nano-lantern (GeNL), a genetically encoded bioluminescent oxygen indicator for Po2 imaging. In awake behaving mice, we uncover the existence of spontaneous, spatially defined "hypoxic pockets" and demonstrate their linkage to the abrogation of local capillary flow. Exercise reduced the burden of hypoxic pockets by 52% compared with rest. The study provides insight into cortical oxygen dynamics in awake behaving animals and concurrently establishes a tool to delineate the importance of oxygen tension in physiological processes and neurological diseases.
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