旋回作用
灰质
基于体素的形态计量学
缘上回
脑形态计量学
萎缩
梭状回
炎症性肠病
神经影像学
体素
白质
病理
医学
心理学
神经科学
疾病
磁共振成像
大脑皮层
认知
放射科
功能磁共振成像
作者
Jennifer Kornelsen,Theresa A. McIver,Md Nasir Uddin,Chase R. Figley,Ruth Ann Marrie,Ronak Patel,John D. Fisk,Sean Carter,Lesley A. Graff,Erin L. Mazerolle,Çharles N. Bernstein
标识
DOI:10.1016/j.brainresbull.2023.110771
摘要
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by inflammation of the gastrointestinal tract and is a disorder of the brain-gut axis. Neuroimaging studies of brain function and structure have helped better understand the relationships between the brain, gut, and comorbidity in IBD. Studies of brain structure have primarily employed voxel-based morphometry to measure grey matter volume and surface-based morphometry to measure cortical thickness. Far fewer studies have employed other surface-based morphometry metrics such as gyrification, cortical complexity, and sulcal depth. In this study, brain structure differences between 72 adults with IBD and 90 healthy controls were assessed using all five metrics. Significant differences were found for cortical thickness with the IBD group showing extensive left-lateralized thinning, and for cortical complexity with the IBD group showing greater complexity in the left fusiform and right posterior cingulate. No significant differences were found in grey matter volume, gyrification, or sulcal depth. Within the IBD group, a post hoc analysis identified that disease duration is associated with cortical complexity of the right supramarginal gyrus, albeit with a more lenient threshold applied.
科研通智能强力驱动
Strongly Powered by AbleSci AI