SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACIVITY OF SUBSTITUTED 2-AMINOBENZOTHIAZOLE

Heterocyclic compounds and their derivatives have gained popularity due to their prominent medicinal importance, as well as in organic chemistry. The versatile and synthetically accessible 2-aminobenzothiazole scaffolds have the all-round character for multiple applications obviously because they are synthetically accessible. Benzothiazole is a representative class of sulfur containing heterocyclics. Four substituted 2-aminobenzothaizoles were prepared from ammonium thiocyanate and substituted aniline in presence of HCl and ethanol by conventional method. The substituted products were characterized through IR, NMR and Mass spectroscopic methods. The synthesized compounds like substituted 2-aminobenzothiazoles and their derivatives studied for the MIC value by dissolving in ethanol. The effect of electron withdrawing and donating group was studying using serial dilution method.