Fluorescent Porous Materials Based on Aggregation-induced Emission for Biomedical Applications

Fluorescent porous materials based on aggregation-induced emission (AIE) are growing into a sparkling frontier in biomedical applications. Exploring those materials represents a win-win integration and has recently progressed at a rapid pace, mainly benefiting from intrinsic advantages including tunable pore size and structure, strong guest molecule encapsulation ability, superior biocompatibility, and photophysical outcomes. With the great significance and rapid progress in this area, this review provides an integrated picture on AIE luminogen-based porous materials. It encompasses inorganic, organic, and inorganic-organic porous materials, exploring fundamental concepts and the relationship between AIE performance and material design and highlighting significant breakthroughs and the latest trends in biomedical applications. In addition, some critical challenges and future perspectives in the development of AIE luminogen-based porous materials are also discussed.