血红素加氧酶
神经炎症
氧化应激
下调和上调
神经保护
神经退行性变
血红素
药理学
医学
神经科学
生物
内科学
生物化学
炎症
酶
基因
疾病
作者
Jiao Wang,Tapan Behl,Tarapati Rana,Aayush Sehgal,Pranay Wal,Bhagawati Saxena,Shivam Yadav,Syam Mohan,Md. Khalid Anwer,Sridevi Chigurupati,Imran Zaheer,Bairong Shen,Rajeev K. Singla
出处
期刊:Phytomedicine
[Elsevier]
日期:2024-05-01
卷期号:127: 155466-155466
标识
DOI:10.1016/j.phymed.2024.155466
摘要
The heme oxygenase (HO) system plays a significant role in neuroprotection and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 and HO-2, regulates cellular redox balance. HO-1, an antioxidant defense enzyme, is highlighted due to its association with depression, characterized by heightened neuroinflammation and impaired oxidative stress responses.We observed the pathophysiology of HO-1 and phytochemicals as its modulator. We explored Science Direct, Scopus, and PubMed for a comprehensive literature review. Bibliometric and temporal trend analysis were done using VOSviewer.Several phytochemicals can potentially alleviate neuroinflammation and oxidative stress-induced depressive symptoms. These effects result from inhibiting the MAPK and NK-κB pathways - both implicated in the overproduction of pro-inflammatory factors - and from the upregulation of HO-1 expression mediated by Nrf2. Bibliometric and temporal trend analysis further validates these associations.In summary, our findings suggest that antidepressant agents can mitigate neuroinflammation and depressive disorder pathogenesis via the upregulation of HO-1 expression. These agents suppress pro-inflammatory mediators and depressive-like symptoms, demonstrating that HO-1 plays a significant role in the neuroinflammatory process and the development of depression.
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