Hydrogel Loaded with Components for Therapeutic Applications in Hypertrophic Scars and Keloids

增生性瘢痕 增生性瘢痕 生物医学工程 瘢痕疙瘩 医学 材料科学 计算机科学 皮肤病科 疤痕 纳米技术 病理
作者
Yixiu Zhong,Youfan Zhang,Beibei Lü,Zhenjun Deng,Zhiwen Zhang,Qi Wang,Jianglin Zhang
出处
期刊:International Journal of Nanomedicine [Dove Medical Press]
卷期号:Volume 19: 883-899 被引量:5
标识
DOI:10.2147/ijn.s448667
摘要

Hypertrophic scars and keloids are common fibroproliferative diseases following injury.Patients with pathologic scars suffer from impaired quality of life and psychological health due to appearance disfiguration, itch, pain, and movement disorders.Recently, the advancement of hydrogels in biomedical fields has brought a variety of novel materials, methods and therapeutic targets for treating hypertrophic scars and keloids, which exhibit broad prospects.This review has summarized current research on hydrogels and loaded components used in preventing and treating hypertrophic scars and keloids.These hydrogels attenuate keloid and hypertrophic scar formation and progression by loading organic chemicals, drugs, or bioactive molecules (such as growth factors, genes, proteins/peptides, and stem cells/exosomes).Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favoured by researchers.In addition, combining hydrogels and current therapy (such as laser or radiation therapy, etc.) could improve the treatment of hypertrophic scars and keloids.Then, the difficulties and limitations of the current research and possible suggestions for improvement are listed.Moreover, we also propose novel strategies for facilitating the construction of target multifunctional hydrogels in the future.
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