Cardiac angiosarcoma detected using 68Ga-fibroblast activation protein inhibitor positron emission tomography/magnetic resonance

A 31-year-old woman presented with a 2-month history of chest pain and dyspnoea. Chest computed tomography (CT) and ultrasonography showed massive pericardial effusion. Pericardiocentesis drained the bloody pericardial effusion. A malignant disease was suggested. The patient underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to detect the primary tumour. However, no abnormal activity was observed on maximum intensity projection (Panel A). Follow-up with 68Ga-fibroblast activation protein inhibitor (FAPI) PET/CT was performed to improve detection. A focus with increased 68Ga-FAPI uptake in the right chest was revealed (arrow) (Panel B). The axial PET/CT views localized this abnormality in the right atrium (arrow), with...