Effects of Androgen on Ultrastructure of Corneal Epithelium and Function of the Tear Film in BALB/c Mice

Persistent corneal staining, decreased tear production, short break-up time, and unhealthy corneal ultrastructure were observed in mice that received orchiectomy for at least 8 weeks. A mouse that received orchiectomy could be used as a dry eye model. Exogenous DHT supplement improved corneal epithelial ultrastructure and tear film function in this model.