Effects of probiotics combined with early enteral nutrition on patients with severe acute pancreatitis: a meta analysis

Objective: To systematically review the effect of combined treatment of probiotics and early enteral nutrition for severe acute pancreatitis( SAP). Methods: Randomized controlled trials of probiotics combined with early enteral nutrition on patients with SAP were searched in Medline( from 1996 to Feb. 2014),CNKI( from 1992 to Feb. 2014) and WANFANG DATA( from 1992 to Feb. 2014). Data of included studies were extracted and analyzed by Review Man 5. 1 software. Results: Six studies were included in this review. The results showed that there were significant differences between intervention and control group in the infection rate [OR =0. 21,95% CI( 0. 12,0. 38) ],mortality rate [OR = 0. 37,95% CI( 0. 14,0. 94) ],length of stay [WMD =- 10. 93,95% CI(- 13. 92,- 7. 93) ] and cost of hospitalization [WMD =- 1. 39,95% CI(- 1. 70,- 1. 09) ] related to SAP. Conclusion: Findings from studies included indicate a potential benefit of combined treatment of probiotics early enteral nutrition,which and reduce the risk of infection and death,as well as length of stay and cost related to SAP.