Progress of drug delivery technologies for long-acting injections

With the constant development of science and technology,people's demand for drug therapy effect has become higher and higher.Due to the fact that long-acting injection can prolong the action time,reduce the frequency of administration and improve the patient compliance,it has become a hot area of pharmaceutic research.In this review,we introduced sustained-release drug delivery systems and reviewed the application of the technologies such as prodrug,PEGylation,microspheres,insoluble salts technology,injectable implants,DepoFoam technology and temperature-sensitive in situ gel in the development of long-acting injections.