伏隔核
多巴胺能
神经科学
微透析
光遗传学
中边缘通路
被盖腹侧区
奖励制度
多巴胺
脑刺激奖励
多巴胺能途径
心理学
作者
Moe Watanabe,Minoru Narita
标识
DOI:10.1007/978-981-13-1756-9_17
摘要
Pain plays an important role in alerting the body to potential tissue injury and drives behavior that protects the body from further harm. In contrast, chronic pain does not serve this function and instead only provides a persistent sensation of pain and a negative experience. The mesolimbic dopaminergic system has been recognized to play a central role in motivated behaviors, including various types of reward and pleasure. Many dopaminergic neurons may release multiple neurotransmitters, and the physiological role of the co-release of these transmitters has been revealed incrementally. However, it was not yet clear whether the mesolimbic dopaminergic system and small molecules released in the nucleus accumbens (N.Acc.), the input region of mesolimbic dopaminergic neurons, are involved in pain modulation. Recently, we revealed that the mesolimbic dopaminergic system and small molecules released in the N.Acc. could contribute to pain modulation. In this review, we provide an overview of the relationship between pain and the brain reward circuit using a combination of optogenetics, electrophysiology, and in vivo microdialysis/mass spectrometry integrated system.
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