手性(物理)
化学
等离子体子
表面等离子共振
拉曼光学活性
对映体
纳米材料
纳米技术
纳米颗粒
分子
纳米团簇
共振(粒子物理)
立体化学
有机化学
材料科学
光电子学
物理
粒子物理学
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
夸克
作者
Saeideh Ostovar Pour,Louise Rocks,Karen Faulds,Duncan Graham,Václav Parchaňský,Petr Bouř,Ewan W. Blanch
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2015-06-15
卷期号:7 (7): 591-596
被引量:103
摘要
The ability to detect chirality gives stereochemically attuned nanosensors the potential to revolutionize the study of biomolecular processes. Such devices may structurally characterize the mechanisms of protein-ligand binding, the intermediates of amyloidogenic diseases and the effects of phosphorylation and glycosylation. We demonstrate that single nanoparticle plasmonic reporters, or nanotags, can enable a stereochemical response to be transmitted from a chiral analyte to an achiral benzotriazole dye molecule in the vicinity of a plasmon resonance from an achiral metallic nanostructure. The transfer of chirality was verified by the measurement of mirror image surface enhanced resonance Raman optical activity spectra for the two enantiomers of both ribose and tryptophan. Computational modelling confirms these observations and reveals the novel chirality transfer mechanism responsible. This is the first report of colloidal metal nanoparticles in the form of single plasmonic substrates displaying an intrinsic chiral sensitivity once attached to a chiral molecule.
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