Parkinson’s disease affects network of brain regions that controls whole-body action

Precision brain imaging of individuals with Parkinson’s disease reveals that the affected circuit is best characterized as a previously described network of brain regions called the somato-cognitive action network. Abnormally high connectivity in this network is associated with Parkinson’s disease and is normalized by effective pharmacological treatment and various brain-stimulation therapies. A network called SCAN shows abnormally high connectivity with deep brain structures in people with Parkinson’s disease.