转移
乳腺癌
癌症研究
癌细胞
CCL18型
上皮-间质转换
间充质干细胞
癌症
医学
生物
免疫学
内科学
趋化因子
病理
免疫系统
作者
Shicheng Su,Qiang Liu,Jingqi Chen,Jianing Chen,Fei Chen,Chonghua He,Di Huang,Wei Wu,Ling Lin,Wei Huang,Jin Zhang,Xiaona Cui,Fang Zheng,Haiyan Li,Herui Yao,Fengxi Su,Erwei Song
出处
期刊:Cancer Cell
[Elsevier]
日期:2014-05-01
卷期号:25 (5): 605-620
被引量:605
标识
DOI:10.1016/j.ccr.2014.03.021
摘要
Summary
The close vicinity of cancer cells undergoing epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) at the invasive front of tumors suggests that these two cell type may mutually interact. We show that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF. Reciprocally, CCL18 from TAMs induces cancer cell EMT, forming a positive feedback loop, in coculture systems and humanized mice. Inhibition of GM-CSF or CCL18 breaks this loop and reduces cancer metastasis. High GM-CSF expression in breast cancer samples is associated with more CCL18+ macrophages, cancer cell EMT, enhanced metastasis, and reduced patient survival. These findings suggest that a positive feedback loop between GM-CSF and CCL18 is important in breast cancer metastasis.
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