THE EXPRESSION AND ITS SIGNIFICANCE OF Notch1 PROTEIN IN LYMPHOMA

Objective To explore the expression and its significance of Notch1 protein in lymphoma. Methods By employing immunohistochemistry SP staining,the expressions of Notch1 in 50 lymphomas(30 T-cell lymphomas,13 B-cell lymphomas,and seven Hodgkin lymphomas) were detected,and 15 cases with lymph-node reactive hyperplasia served as controls. Results The positive expression rates of Notch1 in T-cell lymphoma,Hodgkin lymphoma and B-cell lymphoma were 70.00%(21/30),71.40%(5/7) and 23.80%(3/13),respectively.The expression of Notch1 was higher in Hodgkin lymphoma and T-cell lymphoma than that in the control and B-cell lymphoma(χ2=16.052,8.097;P=0.004;P0.05),the expression,however,between the control and B-cell lymphoma,Hodgkin lymphoma and T-cell lymphoma was not statistically different(P0.05). Conclusion The overexpression of Notch1 protein is probably related with the occurrence of lymphoma,the effect of Notch1 on the development of different-type lymphoma may be various.