Expression and significance of DCC and Ki67 in cervical intraepithelial neoplasia and cervical cancer

Objective To investigate the expressions and clinical significance of DCC and Ki67 in cervical intraepithelial neoplasia(CIN) and cervical cancer. Methods Immunohistochemistry(SP method) was used to detect the expressions of DCC and Ki67 in 16 cases of CIN and 49 cases of cervical cancer.Results The positive expression rate of DCC and Ki67 in chronic cervicitis,CIN Ⅰ~Ⅱ,CIN Ⅲ and cervical cancer were 75.0%,50.0%,37.5%,24.2% and 10.0%,43.8%,75. 0%,87.9% respectively. The positive expression rate of DCC was significantly different between cervical cancer,CIN Ⅲ and chronic cervicitis(P0.05). The positive expression rate of DCC was not related with age,clinical stage and pathologic grade of cervical cancer(P0.05).The expressions of Ki67 in CIN Ⅰ~Ⅱ,chronic cervicitis and cervical cancer were positively correlated with clinical stage and pathological grade of cervical cancer (P0.05). Conclusion DCC test is helpful to the early diagnosis of cervical cancer,while the detection of Ki67 is not only contribute to the early diagnosis of cervical cancer,but also to monitor the development of cervical cancer,which also is an important indicator for patients 'prognosis.