Objective:To analyze the clinical effect of Guxintai in treating fracture,fracture nonunion,osteoporosis,avascular necrosis of femoral head.Methods:246 patients suffered from fracture,fracture nonunion,osteoporosis,avascular necrosis of femoral head were randomly divided into two groups,the treating group(106 cases)and control group(146 cases).Guxintai was used in the treating group.Results:246 cases had been followed up for 5~24 months.The excellent and good rate in treating group of fracture,fracture nonunion,osteoporosis were 87.5%,73.7% and 91.4% respectively higher than that in control group (P0.05).There was no obvious difference in treating and control group of avascular necrosis of femoral head.Conclusion:Guxintai has satisfactory effect in treating fracture,fracture nonunion,osteoporosis and avascular necrosis of femoral head.