Objective To compare the clinical efficacy of percutaneous kyphoplasty(PKP) and percutaneous vertebroplasty(PVP) in the treatment of osteoporotic vertebral compression fractures(OVCF).Methods From Feb.2009 to May 2013,150 cases of OVCF admitted to Chongqing Dongnan Hospital were included.They were divided into PVP group and PKP group by the random number table method.The pain before and 1 day after operation were compared,and the injury vertebral height and kyphosis angle of patients before surgery,1 day and 1 year after operation were recorded.Besides,the height of vertebral loss,leakage of bone cement,and the postoperative occurrences of adjacent vertebral fracture were also compared between the two groups during the one-year follow-up.Results Compared with pre-operation,visual analog scale(VAS) scores of PVP group and PKP group one day after the treatment both decreased significantly(P 0.01) [from(7.81 ± 2.32) to(2.44 ± 0.98),from(7.72 ± 2.21) to(2.38 ± 0.99) ].One day and one year after the treatment,the injury vertebral heights of PVP group were(23.7 ± 2.3) mm,(21.8 ± 2.0)mm respectively,while the kyphotic angles were(17.6 ± 1.9) ° and(18.0 ± 1.9) °.Correspondingly,that PKP of group were(27.5 ± 2.6) mm and(26.6 ± 2.1) mm,(11.8 ± 1.1) ° and(11.9 ± 1.0) °.The injury vertebral heights of both groups increased significantly(P 0.05),while the kyphotic angles decreased significantly(P 0.05).One year after surgery,the vertebral heights loss of PVP group were significantly higher than PKP group [(8.2 ± 0.8) % vs(4.1 ± 0.5) %,P 0.05].There were 17 cases(22.7%) in PVP group with cement leakage,8 cases(10.7%) in PKP group,which showed significant differences(P 0.05).There was no statistically significant difference in the incidence of adjacent vertebral fracture between the two groups after sugery(P 0.05).Conclusion Both PKP and PVP have great curative effects in the treatment of OVCF.However the PKP has better clinical efficacy and less complications.