斑点图案
血流
散斑成像
血流动力学
丘脑
神经影像学
脑血流
临床前影像学
激光多普勒测速
光学
医学
生物医学工程
体内
心脏病学
放射科
物理
生物
生物技术
精神科
作者
Ming Chen,Dong Wen,Shifeng Huang,Shen Gui,Zhihong Zhang,Jian Lü,Pengcheng Li
出处
期刊:Optics Letters
[The Optical Society]
日期:2018-11-14
卷期号:43 (22): 5627-5627
被引量:22
摘要
Poor blood flow circulation can occur in the subcortical regions of the brain in many brain diseases. However, the limitations of light penetration imaging techniques hinder the detection of blood flow in deep brain tissues in vivo. Hence, in this Letter, we present a gradient index lens-based laser speckle contrast imaging system for time-lapse blood flow detection in subcortical regions of the brain. We monitored the hemodynamic changes in the thalamus of mouse models of acute hypoxia and transient middle cerebral artery occlusion as a proof of concept for practical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI