医学
干眼症
口干
治疗效果
皮肤病科
灼口综合征
人造眼泪
眼科
希默试验
外科
作者
Juan Zhang,Hai-Dong Wang,Hui-Jun Yang
出处
期刊:Chinese acupuncture & moxibustion
日期:2019-11-12
卷期号:39 (11): 1173-1176
标识
DOI:10.13703/j.0255-2930.2019.11.010
摘要
Objective To compare the clinical efficacy of needle-knife and hydroxychloroquine sulfate in the treatment of dry mouth and eyes symptoms of primary Sjogren's syndrome. Methods A total of 60 patients with primary Sjogren's syndrome were randomly divided into an observation group and a control group, 30 cases in each group. In the observation group, needle-knife was used in the range of 2 cm and 2-3 cm below the occipital protuberance, the left and right lateral bone edges of the C2 spinous process, between and within the range of 1.5-3 cm beside the C3 and C4 spinous processes, points between the left and right mandibular angle and the mastoid, the treatment was given 1 time a week for 8 times. The hydroxychloroquine sulfate was applied 0.2 g each time, 2 times daily, 4 weeks as a course and a total of 2 courses in the control group. The changes of salivary flow rate, tear volume, serum immunoglobulin IgG, IgA, IgM contents and Chinese medicine symptom score were observed before and after treatment in the two groups, and the efficacy was evaluated. Results The total effective rate in the observation group was 86.7% (26/30), which was better than 70.0% (21/30) in the control group (P 0.05). Conclusion Needle-knife is superior to hydroxychloroquine sulfate in improving dry mouth and eyes symptoms and reducing serum IgG content in patients with primary Sjogren's syndrome.
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