彭布罗利珠单抗
微卫星不稳定性
医学
肿瘤科
结直肠癌
内科学
癌症
癌症研究
免疫疗法
微卫星
遗传学
生物
基因
等位基因
作者
Thierry André,Kai‐Keen Shiu,Tae Won Kim,Benny Vittrup Jensen,Lars Henrik Jensen,Cornelis J.A. Punt,Denis Smith,Rocio García‐Carbonero,Manuel Benavides,Peter Gibbs,Christelle De La Fouchardière,Fernando Rivera,Elena Élez,Johanna C. Bendell,Dung T. Le,Takayuki Yoshino,Eric Van Cutsem,Ping Yang,Mohammed Z.H. Farooqui,Patricia Marinello
标识
DOI：10.1056/nejmoa2017699
摘要
Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) tumors after previous therapy. The efficacy of PD-1 blockade as compared with chemotherapy as first-line therapy for MSI-H–dMMR advanced or metastatic colorectal cancer is unknown.
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