Cytokines of the IL-6 family in the modulation of carbohydrate and lipid metabolism in patients with metabolic syndrome

According to the world community, metabolic complications are associated with inflammation in obesity. The cytokines of the interleukins-6 (IL-6) family consist of IL-6, IL-11, IL-27 and have similar, but individual effects, such as the control of liver damage, the balance between metabolic status. IL-6 is ambiguous and has inflammatory properties, regenerative and anti-inflammatory effects. It was established that pathological effects are trained by signal transduction, and anti-inflammatory effects are trained by classical signal transduction. The purpose of the study was to evaluate the role of the IL-6 and his receptors sIL-6Ra, gp130/sIL-6Rb in the regulation of carbohydrate (glucose level) and lipid (cholesterol (Hol), low-density lipoprotein (LDL), triglycerides (TR), high-density lipoprotein (HDL)) exchanges in serum / plasma in patients with metabolic syndrome (MetS). This fact may indicate the protective role of sIL-6Ra trans-signaling and protective role of IL-6 signal inhibition due to high levels of sgp130 / sIL-6Rb in relation to metabolic disorders in obesity patients.