生物
脆弱类杆菌
结直肠癌
微生物群
肠道菌群
拟杆菌
计算生物学
表型
微生物学
阶段(地层学)
癌症研究
基因
DNA错配修复
癌症
克拉斯
遗传学
转录组
基因组
癌变
作者
Melissa C. Kordahi,Ian B. Stanaway,Marion Avril,Denise Chac,Marie-Pierre Blanc,Benjamin D. Ross,Christian Diener,Sumita Jain,Paul McCleary,Ana Parker,Vincent Friedman,Jennifer Z. Huang,Wynn Burke,Sean M. Gibbons,Amy D. Willis,Richard P. Darveau,William M. Grady,Cynthia W. Ko,R. William DePaolo
标识
DOI:10.1016/j.chom.2021.08.013
摘要
Colorectal cancer is a major health concern worldwide. Growing evidence for the role of the gut microbiota in the initiation of CRC has sparked interest in approaches that target these microorganisms. However, little is known about the composition and role of the microbiota associated with precancerous polyps. Here, we found distinct microbial signatures between patients with and without polyps and between polyp subtypes using sequencing and culturing techniques. We found a correlation between Bacteroides fragilis recovered and the level of inflammatory cytokines in the mucosa adjacent to the polyp. Additional analysis revealed that B. fragilis from patients with polyps are bft-negative, activate NF-κB through Toll-like receptor 4, induce a pro-inflammatory response, and are enriched in genes associated with LPS biosynthesis. This study provides fundamental insight into the microbial microenvironment of the pre-neoplastic polyp by highlighting strain-specific genomic and proteomic differences, as well as more broad compositional differences in the microbiome.
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