解脲支原体
医学
产科
人型支原体
细菌性阴道病
妊娠期
无症状的
支原体
前瞻性队列研究
风险因素
性器官
优势比
解脲支原体
怀孕
胎龄
妇科
内科学
生物
遗传学
作者
Giulia Karnauchovas Porto Cunha,Larissa Brito Bastos,Stella Felippe de Freitas,Ricardo Carvalho Cavalli,Silvana Maria Quintana
标识
DOI:10.1111/1471-0528.16949
摘要
To assess the risk of spontaneous preterm birth (sPTB) associated with genital mycoplasma infection in asymptomatic women.Prospective cohort.Public and private health services in Ribeirão Preto, SP, Brazil.A cohort of 1349 asymptomatic women with a singleton pregnancy at 20-25 weeks of gestation.Participants completed a sociodemographic and clinical history questionnaire during the prenatal visit and provided cervicovaginal samples for the evaluation of Mycoplasma hominis (Mh), Ureaplasma spp. and bacterial vaginosis (BV). For gestational outcome, information about the delivery was assessed and sPTB was defined as a birth that occurred before 37 weeks of gestation. The association between variables and the risk of sPTB was evaluated using logistic regression analysis to estimate the odds ratios (ORs).Genital mycoplasma infection and prematurity.The prevalence of sPTB and genital mycoplasma was 6.8 and 18%, respectively. The infection was not a risk factor for sPTB (aOR 0.66, 95% CI 0.32-1.35), even when Mh and Ureaplasma spp. were found together (P = 0.83). Pregnant women with genital mycoplasma infections had greater BV (P < 0.0001), but this vaginal microbiota condition was not associated with sPTB (P = 0.35). Regarding the risk factors associated with sPTB, a previous history of sPTB (aOR 12.06, 95% CI 6.21-23.43) and a cervical length of ≤2.5 cm (aOR 3.97, 95% CI 1.67-9.47) were significant.Genital mycoplasma infection was not a risk factor for sPTB, even in the presence of other abnormal vaginal microbiota.Genital mycoplasma infection was not a risk for sPTB, even when associated with bacterial vaginosis (BV).
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