医学
恶性胸腔积液
内科学
卵巢癌
肿瘤科
癌病
癌症
转移
胸腔积液
腹水
胃肠病学
化疗
作者
Sara Nasser,Christina Fotopoulou,Rolf Richter,Jana Kaulich,Elena Ioana Braicu,Carmen Beteta,Jessica Olschewski,Aygun Babayeva,Jalid Sehouli
标识
DOI:10.21873/anticanres.14971
摘要
AIM To demonstrate the prognostic value of pleural carcinosis/effusion in a cohort of patients with advanced epithelial ovarian cancer (EOC) and the associated therapeutic implications. PATIENTS AND METHODS Overall, data for 388 patients with EOC with confirmed malignant pleural effusion (MPE) or pleural carcinosis were retrospectively analyzed. Exclusion criteria were non-epithelial ovarian malignancies and presence of other comorbidities associated with pleural effusions. RESULTS The prognosis after the occurrence of MPE during the EOC in relapsed cases was poor with an overall survival of 9.9 months. In the multivariate analysis, the time point of the manifestation of the pleural effusion (p<0.001), platinum sensitivity (p=0.003), performance status (p=0.045) and presence of ascites (p=0.004) were significant prognostic factors for overall survival. CONCLUSION Even in this less favorable collective, well-established EOC prognostic factors were associated with a significantly better overall survival. This suggests that the overall behavioral pattern of the disease has strong similarities in patients with and without pleural effusion or carcinosis and merits an equally high therapeutic effort.
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