间充质干细胞
医学
干细胞
旁分泌信号
干细胞疗法
祖细胞
再生(生物学)
临床试验
细胞疗法
疾病
生物信息学
病理
内科学
细胞生物学
生物
受体
作者
Merlin Sobia Poomani,Iyyadurai Mariappan,Ramachandran Perumal,Rathika Regurajan,Krishnaveni Muthan,Venkatesh Subramanian
出处
期刊:Global heart
日期:2022-01-01
卷期号:17 (1)
被引量:14
摘要
Although tremendous progress has been made in conventional treatment for ischemic heart disease, it still remains a major cause of death and disability. Cell-based therapeutics holds an exciting frontier of research for complete cardiac recuperation. The capacity of diverse stem and progenitor cells to stimulate cardiac renewal has been analysed, with promising results in both pre-clinical and clinical trials. Mesenchymal stem cells have been ascertained to have regenerative ability via a variety of mechanisms, including differentiation from the mesoderm lineage, immunomodulatory properties, and paracrine effects. Also, their availability, maintenance, and ability to replenish endogenous stem cell niches have rendered them suitable for front-line research. This review schemes to outline the use of mesenchymal stem cell therapeutics for ischemic heart disease, their characteristics, the potent mechanisms of mesenchymal stem cell-based heart regeneration, and highlight preclinical data. Additionally, we discuss the results of the clinical trials to date as well as ongoing clinical trials on ischemic heart disease.
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