Local Anesthetics

Chapter 14 Local Anesthetics Catherine M. Creighton, Catherine M. CreightonSearch for more papers by this authorLeigh Lamont, Leigh LamontSearch for more papers by this author Catherine M. Creighton, Catherine M. CreightonSearch for more papers by this authorLeigh Lamont, Leigh LamontSearch for more papers by this author Book Editor(s):Tom Doherty MVB, MSc, DACVAA, Tom Doherty MVB, MSc, DACVAA Retired from the College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USASearch for more papers by this authorAlex Valverde DVM, DVSc, DACVAA, Alex Valverde DVM, DVSc, DACVAA Ontario Veterinary College, University of Guelph, Guelph, Ontario, CanadaSearch for more papers by this authorRachel A. Reed DVM, DACVAA, Rachel A. Reed DVM, DACVAA College of Veterinary Medicine, University of Georgia, Athens, GA, USASearch for more papers by this author First published: 26 November 2021 https://doi.org/10.1002/9781119631316.ch14 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary This chapter presents the mechanism of action, physicochemical properties, pharmacokinetics of local anesthetics, and discusses the local anesthetic adjuvants and combinations. In equine practice, local anesthetics are commonly administered to produce local or regional anesthesia/analgesia via: perineural injection, intraarticular injection, epidural injection, tissue infiltration, and topical administration. Local anesthetic molecules have three components: lipophilic group, hydrophilic group, and connecting intermediate chain. Biotransformation of local anesthetics depends on the chemical structure of the drug. The chapter discusses the local anesthetic toxicity. Toxicities can be divided into three categories: systemic, local tissue toxicity, and allergic. The chapter provides the local anesthetic agents, such as lidocaine, mepivacaine, bupivacaine, ropivacaine, proparacaine and tetracaine, and procaine. Manual of Equine Anesthesia and Analgesia, Second Edition RelatedInformation