超氧化物歧化酶
化学
过氧化氢酶
醇脱氢酶
抗氧化剂
乳酸脱氢酶
谷胱甘肽过氧化物酶
阿魏酸
生物化学
CYP2E1
乙醛
食品科学
药理学
酶
乙醇
细胞色素P450
医学
作者
Yuan Gao,Hangjun Chen,Ruiling Liu,Wei Wu,Honglei Mu,Yanchao Han,Hailong Yang,Haiyan Gao
出处
期刊:Food Chemistry
[Elsevier]
日期:2022-06-01
卷期号:378: 132122-132122
被引量:15
标识
DOI:10.1016/j.foodchem.2022.132122
摘要
In this study, the ameliorative effect of water bamboo shoot (WBS) on acute alcoholism mice was investigated and potential biological compounds were explored. Results showed that extraction methods significantly affected the active substances contents and bioactivities of WBS. Principal component analysis (PCA) showed that alkali extract (NE) obtained the highest score, therefore, it was selected for further analysis. Animal experiments showed that NE demonstrated ameliorative effects on acute alcoholism mice as evident by significantly elevated activities of dehydrogenase (alcohol dehydrogenase, acetaldehyde dehydrogenase) and antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase), whereas significantly reduced the levels of aminotransferase (alanine aminotransferase, aspartate aminotransferase) in serum. The potential bioactive activity compounds of NE were explored by UPLC-MS/MS and bioinformatics analysis. Butyl isobutyl phthalate vanillin, ferulic acid methyl ester might be the major compounds in NE on alleviating acute alcoholism. These results indicated that WBS possesses potential ameliorating effect on acute alcoholism.
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