Dual-Powered Nanomotor In Situ Vaccine with Tumor-Confined Penetration and Acidity Neutralization Boosts Stimulator of Interferon Genes-Mediated Immunotherapy

and cGAMP that cooperatively trigger STING signaling, thereby reprogramming tumor-associated macrophages and enhancing cytotoxic T cells infiltration, leading to excellent systemic antitumor immunity in combination with anti-PD-L1 antibodies in multiple tumor models. This work would potentially shift the current ISV design by introducing nanomaterials with tumor-specific autonomy.