化学
芳基
烯丙基重排
亲核细胞
药物化学
相伴的
正在离开组
有机化学
催化作用
烷基
统计
数学
作者
Jiantao Zhang,Weiming Zhu,Peng Zhou,Cui Chen,Xianwei Li,Weibing Liu
标识
DOI:10.1002/adsc.202300828
摘要
Abstract A radical‐induced dichloromethylation and concomitant 1,2‐aryl migration of allylic alcohols with CHCl 3 is developed for the construction of γ,γ‐dichloroketones in moderate to good yields. We found that, for the para ‐substituted unsymmetrical substrates, the more electron‐deficient aryl group migrates preferentially over the more electron‐rich aryl group. Moreover, chlorocyclopropanes could be obtained from allyl alcohols in one‐pot manner through radical‐addition/1,2‐aryl migration/nucleophilic substitution.
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