雌激素
MCF-7型
圆二色性
化学
雌激素受体
立体化学
化学结构
生物化学
癌细胞
人体乳房
内科学
内分泌学
癌症
有机化学
生物
乳腺癌
医学
作者
Haeun Kwon,Quynh Nguyen,Seung Mok Ryu,Jae‐Young Kwon,Sojung Park,Yuanqiang Guo,Bang Yeon Hwang,Joung Han Yim,Jae‐Jin Kim,Ki Sung Kang,Dong‐Ho Lee
标识
DOI:10.1016/j.phytol.2022.10.008
摘要
Estrogen is a vital hormone responsible for the development of the female reproductive system. Hence, estrogen deficiency in menopause increases various symptoms. This study aimed to discover biologically active compounds from an EtOAc-extract of Neopestalotiopsis clavispora culture medium which has previously shown estrogenic activity. A new α-pyrone (1) and a new tetramic acid derivative (2), together with hymenosetin (3) and pestalotiollide B (4), were isolated from the extract. The chemical structures of the new compounds were elucidated using MS and NMR spectroscopy, and the absolute configurations were established by quantum mechanical calculations of electronic circular dichroism and gauge-including atomic orbital NMR chemical shift, followed by DP4 + analysis. The isolated compounds were initially tested for their estrogenic activities using MCF-7 estrogen responsive human breast cancer cells. Hymenosetin (3) showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 2.5 μM via the phosphorylation of estrogen receptor-α.
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