紫苏
关节炎
类风湿性关节炎
细胞生物学
紫苏
刺激
白细胞介素17
免疫学
分泌物
信号转导
T细胞
化学
癌症研究
生物
炎症
内分泌学
免疫系统
生物化学
有机化学
原材料
作者
Akira Maeda,Kouki Hirano,Shingo Maeda,Ayana Okuizumi,Naoya Hirakawa,Kenji Baba,Takashi Fujimura,Seiji Kawamoto
标识
DOI:10.1016/j.bbrc.2022.11.033
摘要
IL-17-producing T-helper 17 (Th17) cells are involved in the pathogenesis of autoimmune disorders such as rheumatoid arthritis (RA). Here, we show that a methoxyflavanone from the Asian medicinal herb Perilla frutescens (termed Perilla-derived methoxyflavanone, PDMF) suppresses Th17 response and collagen-induced arthritis (CIA), an animal model of RA. We found that co-stimulation with PDMF suppressed Th17 cell differentiation and inhibited IL-17A secretion by differentiated Th17 cells. In vivo administration of PDMF to a CIA mouse model significantly ameliorated the development of RA-like joint symptoms, accompanied by decreased IL-17A production. Mechanistically, PDMF neither suppresses Th17-inducing IL-6 signaling nor reciprocally expands regulatory T (Treg) cells, but rather negatively regulates T-cell receptor (TCR) signaling-driven activation of Akt, which is another positive regulator of Th17 cell differentiation. These results suggest that PDMF is useful in preventing RA and the pro-inflammatory Th17 response.
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