肠神经系统
神经嵴
医学
神经科学
背景(考古学)
运动性
卡哈尔间质细胞
巨结肠病
胚胎学
解剖
病理
神经系统
疾病
生物
细胞生物学
胚胎
免疫组织化学
古生物学
作者
Ha Jerry Long Hei,Lui Vincent Chi Hang,Tam Paul Kwong Hang
标识
DOI:10.1016/j.sempedsurg.2022.151227
摘要
Bowel has its own elegant nervous system - the enteric nervous system (ENS) which is a complex network of neurons and glial clones. Derived from neural crest cells (NCCs), this little brain controls muscle contraction, motility, and bowel activities in response to stimuli. Failure of developing enteric ganglia at the distal bowel results in intestinal obstruction and Hirschsprung disease (HSCR). This Review summarises the important embryological development of the ENS including proliferation, migration, and differentiation of NCCs. We address the signalling pathways which determine NCC cell fate and discuss how they are altered in the context of HSCR. Finally, we outline the anatomical defects and the mechanisms underlying gut motility in HSCR.
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