Acid-sensitive PEG-removable nanoscale liposomes for delivery of doxorubicin in A549/ADR therapy

Acid-sensitive PEG-removable mPEG-NCH-DOB was prepared for modification of liposomes PHDGX to overcome the “PEG dilemma”. PHDGX can accelerate the release of DOX in acidic media and overcome the DOX resistance of A549/ADR at low DOX concentrations.