Total synthesis, structure elucidation and expanded bioactivity of icosalide A: effect of lipophilicity and ester to amide substitution on its bioactivity

Synthesis, stereo assignment and NMR based three-dimensional conformation of depsipeptide Icosalide A were achieved. SAR study of Icosalide A and its analogues varying in β-hydroxy acids was investigated, further establishing their antituberculosis and anticancer activity.