化学
胺化
分子内力
催化作用
氨
铜
水溶液
原子经济
水介质
组合化学
有机化学
作者
Huifeng Wang,Yaming Li,Linlin Jiang,Rong Zhang,Jin Kun,Defeng Zhao,Chunying Duan
摘要
A wide range of free N-H 2-arylindoles were synthesised via the copper(II)-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization. The convenience and atom economy of aqueous ammonia, and the low cost of the copper catalytic system make this protocol readily superior in practical application.
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