结直肠癌
发病机制
癌基因
转移
突变
突变体
基因
癌症研究
病理
医学
生物
胃肠病学
内科学
癌症
遗传学
细胞周期
作者
David Sidransky,Takashi Tokino,Stanley R. Hamilton,Kenneth W. Kinzler,Bernard Levin,Philip Frost,Bert Vogelstein
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1992-04-03
卷期号:256 (5053): 102-105
被引量:681
标识
DOI:10.1126/science.1566048
摘要
Colorectal (CR) tumors are usually curable if detected before metastasis. Because genetic alterations are associated with the development of these tumors, mutant genes may be found in the stool of individuals with CR neoplasms. The stools of nine patients whose tumors contained mutations of K-ras were analyzed. In eight of the nine cases, the ras mutations were detectable in DNA purified from the stool. These patients included those with benign and malignant neoplasms from proximal and distal colonic epithelium. Thus, colorectal tumors can be detected by a noninvasive method based on the molecular pathogenesis of the disease.
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