Oligomeric peptides derived from γ-p-nitrobenzyl- L -glutamate. Synthesis and optical activity of the dimer and the trimer

Both the dimer and the trimer of γ-p-nitrobenzyl-L-glutamate have been prepared using either solid phase peptide synthesis or a step-by-step method. From a c.d. study, it has been shown that the nitrobenzylic chromophore is optically active for both oligomers. This result may be explained by folding of the side chain towards the asymmetric carbon atom.