前额叶皮质
内分泌学
内科学
神经营养因子
高架加迷宫
糖皮质激素受体
开阔地
谷氨酸受体
脑源性神经营养因子
心理学
糖皮质激素
医学
海马体
慢性应激
受体
抗抑郁药
焦虑
行为绝望测验
神经科学
精神科
认知
作者
Shuichi Chiba,Tadahiro Numakawa,Midori Ninomiya,Misty Richards,Chisato Wakabayashi,Hiroshi Kunugi
标识
DOI:10.1016/j.pnpbp.2012.05.018
摘要
Stress and the resulting increase in glucocorticoid levels have been implicated in the pathophysiology of depressive disorders. We investigated the effects of chronic restraint stress (CRS: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (GR) expression as well as brain-derived neurotrophic factor (BDNF)-dependent neural function in the prefrontal cortex (PFC). We observed significant reductions in body weight gain, food intake and sucrose preference from 1 week after the onset of CRS. In the 5th week of CRS, we conducted open-field (OFT), elevated plus-maze (EPM) and forced swim tests (FST). We observed a decrease in the number of entries into open arms during the EPM (anxiety-like behavior) and increased immobility during the FST (depression-like behavior). When the PFC was removed after CRS and subject to western blot analysis, the GR expression reduced compared with control, while the levels of BDNF and its receptors remained unchanged. Basal glutamate concentrations in PFC acute slice which were measured by high performance liquid chromatography were not influenced by CRS. However, BDNF-induced glutamate release was attenuated after CRS. These results suggest that reduced GR expression and altered BDNF function may be involved in chronic stress-induced anxiety--and depression-like behaviors.
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