核糖核酸
DNA折纸
DNA
折叠(DSP实现)
计算生物学
纳米技术
DNA纳米技术
核酸结构
化学
生物
基因
遗传学
材料科学
工程类
电气工程
作者
Cody Geary,Paul W. K. Rothemund,Ellen Juul Andersen
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2014-08-15
卷期号:345 (6198): 799-804
被引量:289
标识
DOI:10.1126/science.1253920
摘要
The future of RNA origami writ large Researchers have long fabricated intricate nanostructures from carefully linked DNA strands. Now they can use RNA made by gene expression, which avoids the costly strand synthesis and lengthy annealing steps necessary with DNA origami. Geary et al. used molecular modeling to extend the size of folded RNA origami structures (see the Perspective by Leontis and Westhof). The modeling revealed assembly patterns for linking single-stranded RNA into A-form helices. The authors created two-dimensional structures as large as 660 nucleotides on mica surfaces. Science , this issue p. 799 ; see also p. 732
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