叉头转录因子
亚科
转录因子
福克斯O1
生物
功能(生物学)
病态的
细胞生物学
细胞凋亡
生物信息学
遗传学
医学
内科学
基因
作者
Sarah M. Ronnebaum,Cam Patterson
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2010-03-17
卷期号:72 (1): 81-94
被引量:158
标识
DOI:10.1146/annurev-physiol-021909-135931
摘要
The Forkhead family of transcription factors mediates many aspects of physiology, including stress response, metabolism, commitment to apoptosis, and development. The Forkhead box subfamily O (FoxO) proteins have garnered particular interest due to their involvement in the modulation of cardiovascular biology. In this review, we discuss the mechanisms of FoxO regulation and outcomes of FoxO signaling under normal and pathological cardiovascular contexts.
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