Water-Accelerated Synthesis of Novel Bis-2,3-dihydroquinazolin-4(1H)-one Derivatives

Bisdihydroquinazolinones were synthesized for the first time by a novel pseudo five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent.