医学
巨细胞病毒
炎症性肠病
疾病
结肠炎
胃肠病学
内科学
溃疡性结肠炎
更昔洛韦
免疫学
病毒
病毒性疾病
人巨细胞病毒
疱疹病毒科
作者
Yael Einbinder,Dana Wolf,Orit Pappo,A Migdal,Eduard Tsvang,Zvi Ackerman
标识
DOI:10.1111/j.1365-2036.2008.03595.x
摘要
Summary Background Colonic cytomegalovirus reactivation rarely occurs in adults without inflammatory bowel disease or a known immunosuppressive state. Aim To describe our experience with such patients. Methods All consecutive admissions of patients with possible cytomegalovirus colitis, between 1995 and 2006, were reviewed retrospectively. Results Nineteen patients were studied. Most of the patients were elderly with multiple co‐morbidities. Three main forms of disease presentation were recognized: acute diarrhoea, chronic diarrhoea and lower gastrointestinal bleeding. Colonic mucosal intranuclear inclusion bodies were found in 12 patients. Thirteen patients had cytomegalovirus viraemia (either by polymerase chain reaction and/or by white blood cell‐cytomegalovirus antigenaemia test). Ganciclovir therapy was given to only eight patients; only five of these patients survived. The other subgroup of 11 patients received only supportive therapy. Most of the patients from this subgroup had a prolonged and complicated hospital course; only nine patients survived. Follow‐up colonoscopies were performed only in five patients (out of the 14 patients who survived). In four of these patients, chronic mucosal inflammatory changes were noted. Conclusions Cytomegalovirus colitis occurs rarely in adult individuals. The disease may have various and multiple acute and/or chronic clinical manifestations. Clinical awareness of this condition is needed.
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