自愈水凝胶
肿胀 的
纤维素
环氧氯丙烷
果胶
化学工程
材料科学
膨胀能力
药物输送
控制释放
聚合物
高分子化学
毒品携带者
核化学
化学
复合材料
纳米技术
生物化学
工程类
作者
Farhana Islam,Siew Yee Wong,Liang Xu,M. Tarik Arafat
出处
期刊:Cellulose
[Springer Nature]
日期:2022-05-08
卷期号:29 (9): 5207-5222
被引量:12
标识
DOI:10.1007/s10570-022-04600-y
摘要
Pectin (Pec) and mucin (Muc) were incorporated into a pure cellulose hydrogel network prepared in a urea/NaOH solvent system and cross-linked with epichlorohydrin to create cellulose-based superabsorbent hydrogels. Hydrogels were also tested for pH-responsive swelling capacity and in vitro drug release behavior. It was observed that swelling ratios increased several folds for the Pec/Muc-modified hydrogels compared to pure cellulose hydrogel and the maximum swelling ratio was 2781% at pH 10 for Pec-modified hydrogel. Besides, different drug release profiles were observed in different pH mediums, where a highly swollen and less eroded matrix showed a slower release due to a larger diffusion path. The incremented swelling ratio of modified hydrogels was attributed to numerous functional groups present on the backbone of the polymers, which aided in forming excessive hydrogen bonds with water. Structural characterization and possible interactions among cellulose and incorporated materials inside the hydrogels were confirmed by attenuated total reflection Fourier transform infrared spectroscopy, field emission scanning electron microscope, and simultaneous thermal analysis. Moreover, the mechanical properties of the Pec and Muc incorporated hydrogels were significantly improved. Owing to the tunable pH-sensitive water absorption, drug release behavior, and improved mechanical properties, Pec/Muc-modified cellulose hydrogels present a wide range of possibilities for further expansion in controlled drug delivery systems and other biomedical applications.Graphical abstract
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