化学
苄胺
甘氨酸
芳基
镍
催化作用
组合化学
小学(天文学)
脱羧
光催化
有机化学
光催化
氨基酸
生物化学
烷基
物理
天文
作者
Takumi Kinoshita,Yuta Makihara,Kei Murakami,Kenichiro Itami,Jae‐Kyung Jung,Yota Sakakibara,Kazuma Amaike
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-07-13
被引量:1
标识
DOI:10.1055/s-0041-1738444
摘要
Abstract Benzylamines are important scaffolds that are ubiquitously found in various bioactive molecules. Among the benzylamine derivatives, primary benzylamines (ArCH2NH2) are regarded as valuable building blocks for pharmaceuticals. Herein, we report decarboxylative aminomethylation of aryl bromides with N-protected glycine under nickel/photoredox-catalyzed conditions. The corresponding products can be easily deprotected under acidic conditions to give primary benzylamines.
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